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Zymocell 2G

Pharmacokinetics

Oral tablets release their main active ingredients in the intestine, from where they are absorbed into the bloodstream by active transport through the chyliferous membranes.

In the case of the injectable form, the active substances are absorbed into the bloodstream quickly. A significant part of the dosage, between 20 and 60% of the dose administered, is reabsorbed as biologically intact molecules; 4 to 6 hours later, maximum concentrations have been found in the plasma, which tend to last approximately 24 hours. After absorption, the enzymes are distributed systemically, acting especially at the site where a disease produced by deficiency of the same is located. This spot-targeting is based on the interaction with alpha-2 macroglobulin, a substance produced by activated immunological cells (macrophages/monocytes). The enzymes absorbed are eliminated at the level of the liver by other cells of the mononuclear phagocytic system, and ultimately through faecal excretion.

 


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